Research Activities

Genomic and proteomic analysis

Marine Genomics and Proteomics research under Silver Lab focusing on the development of genetics and genomics technologies, together with associated laboratory automation systems, data analysis, and information management tools. The laboratory develops integrated strategies using multiple technology platforms that maximize the value of research or clinical samples and lead to the identification of pathways, genes, or gene products involved in the development of a disease, as well as the assembly of genetic or expression profiles for the identification of prognostic and diagnostic indicators. The laboratory also specializes in the development of custom assays for quantitation of specific molecules in complex clinical samples. we look at the gene expression of pathway genes and figure out which genes are up-regulated and which are down-regulated. Analyzing protein biomarkers in biological samples using native and SDS-PAGE allows us to determine their identities. We also use various molecular markers to learn about genetic diversity, population genetics, and gene flow through DNA fingerprinting. We also study molecular docking of protein-ligand interactions, protein-protein interactions, and in-silico analysis of single nucleotide polymorphism.

Microbial genomics and transcriptomics

Centre for marine microbial research under Silver Lab has concentrated on the Metagenomics, Transcriptomic analysis for disease diagnosis, Microbial genomics and bioinformatics research. Metagenomics analysis, can reveal the genetic content of entire communities of cultured and uncultured organism. Direct genomics analysis, cloning, library construction of environmental DNA from sediment, water and other biological sample can be analysed. In addition, the rapid next generation sequencing, Individual microbial gene sequencing also analysed and further DNA assembling, vector screening, NCBI submission, Phylogenetic analysis also be done. Further, Transcriptomic analysis for gene level differential expression, up and down regulation of metabolic pathways in various diseases. Apart from this, homology modelling and their structure prediction can be analysed.

bioactive compounds and therapeutics

Molluscan and arthropod exoskeletons (Cuttlebone, Gladius, and outer shell) contain bioactive substances (Chitin, chitosan, collagen, and gelatin) that can be isolated, characterized, and have bioactive potentials (antimicrobial, antioxidant, anticoagulant, and wound healing). Synthesize chitosan nanoparticles and characterize them as well as explore their potentials. Additional research on marine microorganisms' quorum sensing capabilities and corrosion control/prevention related projects.

Energy and environmental analysis

Material Chemistry Division under Silver Lab focus on the synthesis and fabrication of highly stable noble and non-noble metal based Oxides, Sulphides, Oxyhalides, Tungstaes, Vanadates and Molybdates nanostructure by various chemical methods. Carbon Based Materials (rGO, g-C3N4 and its metal and non-metal doped materials) will be synthesized. Nano hybrids of both Nps and CBM will be done by various chemical method. Synthesis of the nanomaterial’s will be done both by template and temple free method. The synthesized nanomaterial will be utilized for energy and environmental application. In the energy oriented application Supercapacitor, water splitting (HER/OER) and environmental application Photocatalytic degradation of wastewater (Dye, Drug). The working electrodes will be fabricated with high stability. Recycling stability of the photocatalyst will be studied. Electrochemical sensor of biomolecules, drug molecules.

Nanomaterials for Drug delivery and therapeutic Applications

The Silver Lab is devoted to the chemical synthesis and development of highly efficient, stable nano-hetero architecture based on metal oxides, sulfides and carbon-based materials (GO, rGO, SWCNT and MWCNT). The fabricated nanomaterial will be used in environmental, energy-related applications, Drug delivery and therapeutic Applications. Our research interests lie at the intersection of Materials chemistry (exceptionally functional semiconductor materials for biomedical applications) with controlled shapes and sizes for the next generation's biomedical and energy needs. Specifically, understanding Phase-change behaviour on advanced materials was investigated in detail. Some of the size and shape-controlled materials are given below.